Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria.

  title={Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria.},
  author={Eva C. Boritsch and Varun Khanna and Alexandre Pawlik and Nadine Honor{\'e} and Victor H Navas and Laurence Ma and Christiane Bouchier and Torsten Seemann and Philip Supply and Timothy P Stinear and Roland Brosch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 35},
Horizontal gene transfer (HGT) is a major driving force of bacterial diversification and evolution. For tuberculosis-causing mycobacteria, the impact of HGT in the emergence and distribution of dominant lineages remains a matter of debate. Here, by using fluorescence-assisted mating assays and whole genome sequencing, we present unique experimental evidence of chromosomal DNA transfer between tubercle bacilli of the early-branching Mycobacterium canettii clade. We found that the obtained… CONTINUE READING
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Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

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