Key determinants of target DNA recognition by retroviral intasomes

@inproceedings{Serrao2015KeyDO,
  title={Key determinants of target DNA recognition by retroviral intasomes},
  author={Erik Serrao and Allison Ballandras-Colas and Peter Cherepanov and Goedele N Maertens and Alan N. Engelman},
  booktitle={Retrovirology},
  year={2015}
}
Retroviral integration favors weakly conserved palindrome sequences at the sites of viral DNA joining and generates a short (4–6 bp) duplication of host DNA flanking the provirus. We previously determined two key parameters that underlie the target DNA preference for prototype foamy virus (PFV) and human immunodeficiency virus type 1 (HIV-1) integration: flexible pyrimidine (Y)/purine (R) dinucleotide steps at the centers of the integration sites, and base contacts with specific integrase… CONTINUE READING
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