Key binding interactions for memantine in the NMDA receptor.

  title={Key binding interactions for memantine in the NMDA receptor.},
  author={Walrati Limapichat and Wesley Yung-Hsu Yu and Emma Branigan and Henry A. Lester and Dennis A Dougherty},
  journal={ACS chemical neuroscience},
  volume={4 2},
Memantine (Namenda) is prescribed as a treatment for moderate to severe Alzheimer's Disease. Memantine functions by blocking the NMDA receptor, but the key binding interactions between drug and receptor are not fully elucidated. To determine key binding interactions of memantine, we made side-by-side comparisons of IC(50) for memantine and amantadine, a structurally related drug, in the GluN1/GluN2B NMDA receptor. We identified hydrophobic binding pockets for the two methyl groups on memantine… CONTINUE READING
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