Key amino acids located within the transmembrane domains 5 and 7 account for the pharmacological specificity of the human V1b vasopressin receptor.

@article{Derick2004KeyAA,
  title={Key amino acids located within the transmembrane domains 5 and 7 account for the pharmacological specificity of the human V1b vasopressin receptor.},
  author={Sylvain Derick and Alejandro Pe{\~n}a and Thierry Durroux and Jean Wagnon and Claudine Serradeil-Le Gal and Marcel Hibert and Didier Rognan and Gr{\'e}groire Guillon},
  journal={Molecular endocrinology},
  year={2004},
  volume={18 11},
  pages={2777-89}
}
In mammals, the vasopressin V(1b) receptor (V(1b)-R) is known to regulate ACTH secretion and, more recently, stress and anxiety. The characterization of the molecular determinant responsible for its pharmacological selectivity was made possible by the recent discovery of the first V(1b) antagonist, SSR149415. Based upon the structure of the crystallized bovine rhodopsin, we established a three-dimensional molecular model of interaction between the human V(1b)-R (hV(1b)-R) and SSR149415. Four… CONTINUE READING
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