Key Role of Nuclear Factor-κB in the Cellular Pharmacokinetics of Adriamycin in MCF-7/Adr Cells: The Potential Mechanism for Synergy with 20(S)-Ginsenoside Rh2

@article{Zhang2012KeyRO,
  title={Key Role of Nuclear Factor-$\kappa$B in the Cellular Pharmacokinetics of Adriamycin in MCF-7/Adr Cells: The Potential Mechanism for Synergy with 20(S)-Ginsenoside Rh2},
  author={Jingwei Zhang and Meng Lu and Fang Zhou and Haopeng Sun and Gang Hao and Xiaolan Wu and Guangji Wang},
  journal={Drug Metabolism and Disposition},
  year={2012},
  volume={40},
  pages={1900 - 1908}
}
We have previously demonstrated that ginsenoside 20(S)-Rh2 is a potent ATP-binding cassette (ABC) B1 inhibitor and explored the cellular pharmacokinetic mechanisms for its synergistic effect on the cytotoxicity of Adriamycin. The present studies were conducted to elucidate the key factors that influenced ABCB1 expression, which could further alter Adriamycin cellular pharmacokinetics. Meanwhile, the influence of 20(S)-Rh2 on the above factors was revealed for explaining its synergistic effect… 
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