Key Role for Matrix Metalloproteinases -19 and -28 in Maintenance of Intestinal Homeostasis

@inproceedings{Brauer2011KeyRF,
  title={Key Role for Matrix Metalloproteinases -19 and -28 in Maintenance of Intestinal Homeostasis},
  author={Rena Brauer},
  year={2011}
}
The present study investigates the role of two matrix metalloproteinases, MMP-19 and MMP-28, in intestinal homeostasis and inflammation by means of a mouse model for inflammatory bowel disease (IBD). MMP-19 and -28 are abundantly expressed in epithelial tissues. However, their functions in this compartment and their functional overlap have not been elucidated so far. MMP-19 contributes to IGF-signaling, cell proliferation, and migration and is able to cleave several soluble proteins and… CONTINUE READING

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