Key Role for Clumping Factor B in Staphylococcus aureus Nasal Colonization of Humans

@article{Wertheim2008KeyRF,
  title={Key Role for Clumping Factor B in Staphylococcus aureus Nasal Colonization of Humans},
  author={Heiman Frank Louis Wertheim and Evelyn J. Walsh and Roos S R Choudhurry and Damian C. Melles and H{\'e}l{\`e}ne A.M. Boelens and Helen Miajlovi{\'c} and Henri A. Verbrugh and T. J. Foster and Alex van Belkum},
  journal={PLoS Medicine},
  year={2008},
  volume={5},
  pages={811 - 818}
}
BACKGROUND Staphylococcus aureus permanently colonizes the vestibulum nasi of one-fifth of the human population, which is a risk factor for autoinfection. The precise mechanisms whereby S. aureus colonizes the nose are still unknown. The staphylococcal cell-wall protein clumping factor B (ClfB) promotes adhesion to squamous epithelial cells in vitro and might be a physiologically relevant colonization factor. METHODS AND FINDINGS We define the role of the staphylococcal cytokeratin-binding… CONTINUE READING
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