Ketotifen Therapy for Acute Ulcerative Colitis in Children (A Pilot Study)

  title={Ketotifen Therapy for Acute Ulcerative Colitis in Children (A Pilot Study)},
  author={Nicola Louise Jones and Chaim M. Roifman and Anne Marie Griffiths and Philip Sherman},
  journal={Digestive Diseases and Sciences},
Eosinophils contribute to the inflammatoryprocess in a variety of chronic inflammatory boweldiseases. Ketotifen is beneficial in experimental modelsof colitis and in patients with eosinophilicgastroenteritis. Therefore, we investigated the efficacy ofketotifen therapy for the treatment of active ulcerativecolitis. Children with newly or previously diagnosedulcerative colitis with mild-moderate disease activity were treated with ketotifen at a dosage of 4 mgdaily for eight weeks. Efficacy was… CONTINUE READING
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