Ketorolac 0.45% Ophthalmic Solution
@article{McCormack2011Ketorolac0O, title={Ketorolac 0.45\% Ophthalmic Solution}, author={Paul L. McCormack}, journal={Drugs \& Aging}, year={2011}, volume={28}, pages={583-589} }
Ketorolac 0.45% ophthalmic solution is a topical NSAID indicated in the US for the treatment of ocular pain and inflammation following cataract surgery.In animal studies, the ocular relative bioavailability of single-dose topical ketorolac 0.45% ophthalmic solution was 2- to 3-fold higher than that of ketorolac 0.4% ophthalmic solution.In two identically designed, randomized, double-masked, multicentre trials in adult patients undergoing cataract extraction, the proportions of patients with a…
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PURPOSE
Anti-inflammatory activity of topical nonsteroidal anti-inflammatory drugs is mediated by suppression of cyclooxygenase (COX) isoenzymes. This study compared ocular penetration and…