• DOI:10.2165/11207450-000000000-00000
• Corpus ID: 36573017

Ketorolac 0.45% Ophthalmic Solution

@article{McCormack2011Ketorolac0O,
  title={Ketorolac 0.45\% Ophthalmic Solution},
  author={Paul L. McCormack},
  journal={Drugs \& Aging},
  year={2011},
  volume={28},
  pages={583-589}
}

• P. L. McCormack
• Published 1 July 2011
• Medicine
• Drugs & Aging

Ketorolac 0.45% ophthalmic solution is a topical NSAID indicated in the US for the treatment of ocular pain and inflammation following cataract surgery.In animal studies, the ocular relative bioavailability of single-dose topical ketorolac 0.45% ophthalmic solution was 2- to 3-fold higher than that of ketorolac 0.4% ophthalmic solution.In two identically designed, randomized, double-masked, multicentre trials in adult patients undergoing cataract extraction, the proportions of patients with a summed ocular inflammation score of zero for anterior chamber cell count plus anterior chamber flare on day 14 after surgery were significantly greater in those treated with topical ketorolac 0.45% ophthalmic solution than in those treated with vehicle placebo.Compared with placebo, topical ketorolac 0.45% ophthalmic solution significantly increased the proportion of patients who were pain-free on the day after surgery in both trials.Ketorolac 0.45% ophthalmic solution was generally well tolerated in clinical trials with lower overall incidences of treatment-emergent and treatment-related adverse events than placebo, and with no single treatment-related adverse event having a higher incidence than with placebo.