Ketoprofen: A Review of Its Pharmacologic and Clinical Properties

@article{Kantor1986KetoprofenAR,
  title={Ketoprofen: A Review of Its Pharmacologic and Clinical Properties},
  author={Thomas G. Kantor},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={1986},
  volume={6}
}
  • T. Kantor
  • Published 6 May 1986
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Ketoprofen (Orudis), a highly potent and safe nonsteroidal antiinflammatory drug of the propionic acid derivative group, was synthesized in France by Rhône‐Poulenc chemists in 1967, 3 years after the prototype ibuprofen. Ketoprofen was introduced in 1973 in France and the United Kingdom for antiinflammatory use. Today the drug is available in about 80 countries and has recently been approved in the United States for treatment of rheumatoid arthritis and osteoarthritis. The therapeutic… Expand
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Comparison of the anti-inflammatory actions of flunixin and ketoprofen in horses applying PK/PD modelling.
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References

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Ketoprofen (Orudis) in the treatment of juvenile rheumatoid arthritis. A segment I study.
TLDR
Preliminary data suggest ketoprofen's efficacy and safety is comparable to that of other nonsteroidal antiinflammatory drugs. Expand
Ketoprofen (19.583 R.P.) (2-(3-benzoylphenyl)-propionic acid). Main pharmacological properties--outline of toxicological and pharmacokinetic data.
TLDR
Ketoprofen is as potent as indomethacin in the tests for anti-inflammatory and analgesic activity, but its antipyretic and antibradykinin activities and its inhibitory activity against prostaglandin synthesis is respectively 4, 8 and 8 times greater than that of indometHacin. Expand
A comparative trial of ketoprofen and ibuprofen in patients with rheumatic disease.
TLDR
Assessment of symptoms showed that there was a greater, more rapid and more sustained improvement in those patients treated with ketoprofen, leading to the withdrawal of 2 patients in the early stage of the trial. Expand
Ketoprofen - clinical efficacy.
  • R. Grahame
  • Medicine
  • Rheumatology and rehabilitation
  • 1976
TLDR
Adequately controlled trials have established Ketoprofen's undoubted clinical efficacy as an antirheumatic agent in all the major rheumatic diseases, and have demonstrated therapeutic potency, comparable with other established non-steroidal anti-inflammatory analgesic drugs. Expand
LIFE-THREATENING ASTHMA, URTICARIA, AND ANGIOŒDEMA AFTER KETOPROFEN
TLDR
During the second day there was a long gap between vitamin K, doses, and as a result the prothrombin-time rose, so Uda1l8 has recommended that the treatment of serious haemorrhage begin with 50 mg phytonadione by slow intravenous injection in addition to whole blood or plasma. Expand
Ketoprofen‐aspirin interactions
TLDR
The findings indicate that the drug‐drug interaction between aspirin and ketoprofen is complex, and that salicylate enhanced the metabolic conversion of ketop rofen to nonconjugate metabolites. Expand
CLINICAL AND PHARMACOKINETIC EVIDENCE OF A LIFE-THREATENING INTERACTION BETWEEN METHOTREXATE AND KETOPROFEN
TLDR
Co-administration of ketoprofen was found in 4 of 118 cycles of high-dose methotrexate (MTX) analysed retrospectively in thirty-six patients, and this high-risk association between MTX toxicity and ketop rofen may also apply to other non-steroidal anti-inflammatory drugs. Expand
Pharmacokinetics of ketoprofen in patients with chronic renal failure.
TLDR
A reduction of the [51Cr]EDTA clearance was correlated with an increase in the elimination half-life of ketoprofen and the urinary excretion corresponded to results reported by other groups. Expand
A comparative study of benoxaprofen and ketoprofen in ankylosing spondylitis.
TLDR
This study shows that benoxaprofen provides very good therapeutic effectiveness in the treatment of ankylosing spondylitis, confirmed by the absence of any statistically significant difference between the results observed with benoxAProfen and with ketoprofen. Expand
Pharmacokinetics of ketoprofen in the elderly.
TLDR
Results suggest that the glucuroconjugation of ketoprofen is slowed down by age, compared with younger subjects elderly patients showed a significant increase in t1/2,z. Expand
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