Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.

@article{Boccella2019KetonesAP,
  title={Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.},
  author={Serena Boccella and Francesca Guida and Francesco De Logu and Danilo De Gregorio and Mariacristina Mazzitelli and Carmela Belardo and Monica Iannotta and N. Pimentel Serra and Romina Nassini and Vito de Novellis and Pierangelo Geppetti and Sabatino Maione and Livio Luongo},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2019},
  volume={33 1},
  pages={
          1062-1073
        }
}
The mechanisms underlying neuropathic pain are poorly understood. Here we show the unexplored role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in 2 models of neuropathic pain. We used an oral treatment with dimethyl fumarate and the HCAR2 endogenous ligand β-hydroxybutyrate (BHB) in wild-type (WT) and HCAR2-null mice. We found an up-regulation of the HCAR2 in the sciatic nerve and the dorsal root ganglia in neuropathic mice. Accordingly, acute and chronic treatment with… CONTINUE READING