Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism.

@article{Bonuccelli2010KetonesAL,
  title={Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism.},
  author={Gloria Bonuccelli and Aristotelis Tsirigos and Diana Whitaker-Menezes and Stephanos Pavlides and Richard G. Pestell and Barbara Chiavarina and Philippe G Frank and Neal Flomenberg and Anthony Howell and Ubaldo e. Martinez-outschoorn and Federica Sotgia and Michael Phillip Lisanti},
  journal={Cell cycle},
  year={2010},
  volume={9 17},
  pages={3506-14}
}
Previously, we proposed a new model for understanding the "Warburg effect" in tumor metabolism. In this scheme, cancer-associated fibroblasts undergo aerobic glycolysis and the resulting energy-rich metabolites are then transferred to epithelial cancer cells, where they enter the TCA cycle, resulting in high ATP production via oxidative phosphorylation. We have termed this new paradigm "The Reverse Warburg Effect." Here, we directly evaluate whether the end-products of aerobic glycolysis (3… CONTINUE READING
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