Ketone body synthesis in the brain: possible neuroprotective effects.

  title={Ketone body synthesis in the brain: possible neuroprotective effects.},
  author={M {\'A}ngeles Guzm{\'a}n and Cristina Bl{\'a}zquez},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  volume={70 3},
Ketone bodies make an important contribution to brain energy production and biosynthetic processes when glucose becomes scarce. Although it is generally assumed that the liver supplies the brain with ketone bodies, recent evidence shows that cultured astrocytes are also ketogenic cells. Moreover, astrocyte ketogenesis might participate in the control of the survival/death decision of neural cells in at least two manners: first, by scavenging non-esterified fatty acids the ketogenic pathway… CONTINUE READING
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