Ketomethyldipeptides I. A new class of angiotensin converting enzyme inhibitors.


The design rationale for a new series of angiotensin-converting enzyme (ACE) inhibitors which incorporate a ketone substituent into a peptide backbone is described. Molecular regions which were expected to mimic the binding of an N-acyl tripeptide substrate at secondary binding sites S1 and S1' were systematically varied in order to study the specificity of… (More)


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@article{Natarajan1984KetomethyldipeptidesIA, title={Ketomethyldipeptides I. A new class of angiotensin converting enzyme inhibitors.}, author={Sivamani Natarajan and Eric M. Gordon and Edmond Sabo and Jack D. Godfrey and Harold N. Weller and Jelka Pluscec and Marcia Rom and David W. Cushman}, journal={Biochemical and biophysical research communications}, year={1984}, volume={124 1}, pages={141-7} }