Ketolides-telithromycin, an example of a new class of antibacterial agents.

@article{Bryskier2000KetolidestelithromycinAE,
  title={Ketolides-telithromycin, an example of a new class of antibacterial agents.},
  author={Andr{\'e} Bryskier},
  journal={Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases},
  year={2000},
  volume={6 12},
  pages={661-9}
}
  • André Bryskier
  • Published 2000 in
    Clinical microbiology and infection : the…
Ketolides are new medicinal chemical entities. They are obtained by removing the 3-L-cladinose sugar moiety from erythronolide A and oxidation of the resulting 3-hydroxyl. They were designed to overcome erythromycin A resistance within Gram-positive cocci. The 3-keto group is responsible for the lack of induction of macrolide resistance, high stability in acidic environments, and the ability to overcome resistance due to methylation of 23SrRNA. The C11-C12 carbamate ketolides are able to… CONTINUE READING

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