Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections.

@article{Bambeke2008KetolidesPP,
  title={Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections.},
  author={Françoise Van Bambeke and Joerg M. Harms and Yves Van Laethem and Paul M Tulkens},
  journal={Expert opinion on pharmacotherapy},
  year={2008},
  volume={9 2},
  pages={267-83}
}
Ketolides differ from macrolides by removal of the 3-O-cladinose (replaced by a keto group), a 11,12- or 6,11-cyclic moiety and a heteroaryl-alkyl side chain attached to the macrocyclic ring through a suitable linker. These modifications allow for anchoring at two distinct binding sites in the 23S rRNA (increasing activity against erythromycin-susceptible strains and maintaining activity towards Streptococcus pneumoniae resistant to erythromycin A by ribosomal methylation), and make ketolides… CONTINUE READING
14 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…