Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder

  title={Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder},
  author={C. Newell and M. Bomhof and R. Reimer and D. Hittel and J. M. Rho and J. Shearer},
  journal={Molecular Autism},
  • C. Newell, M. Bomhof, +3 authors J. Shearer
  • Published 2016
  • Biology, Medicine
  • Molecular Autism
  • BackgroundGastrointestinal dysfunction and gut microbial composition disturbances have been widely reported in autism spectrum disorder (ASD). This study examines whether gut microbiome disturbances are present in the BTBRT + tf/j (BTBR) mouse model of ASD and if the ketogenic diet, a diet previously shown to elicit therapeutic benefit in this mouse model, is capable of altering the profile.FindingsJuvenile male C57BL/6 (B6) and BTBR mice were fed a standard chow (CH, 13 % kcal fat) or… CONTINUE READING
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