Ketogenic diet delays the phase of circadian rhythms and does not affect AMP-activated protein kinase (AMPK) in mouse liver.

@article{Genzer2015KetogenicDD,
  title={Ketogenic diet delays the phase of circadian rhythms and does not affect AMP-activated protein kinase (AMPK) in mouse liver.},
  author={Yoni Genzer and Maayan Dadon and Chen Burg and Nava Chapnik and Oren Froy},
  journal={Molecular and cellular endocrinology},
  year={2015},
  volume={417},
  pages={124-30}
}
Ketogenic diet (KD) is used for weight loss or to treat epilepsy. KD leads to liver AMP-activated protein kinase (AMPK) activation, which would be expected to inhibit gluconeogenesis. However, KD leads to increased hepatic glucose output. As AMPK and its active phosphorylated form (pAMPK) show circadian oscillation, this discrepancy could stem from wrong… CONTINUE READING