Ketogenic Diet for the Treatment of Refractory Epilepsy in Children: A Systematic Review of Efficacy

  title={Ketogenic Diet for the Treatment of Refractory Epilepsy in Children: A Systematic Review of Efficacy},
  author={Frank V. Lefevre and Naomi E. Aronson},
  pages={e46 - e46}
Objectives. To systematically review and synthesize the available evidence on the efficacy of the ketogenic diet in reducing seizure frequency for children with refractory epilepsy. Data Sources. Medline searches were performed using the keywords epilepsy/therapy, dietary therapy, and epilepsy, and the text word ketogenic diet. The Cochrane Library of clinical trials was searched using the term ketogenic diet. Bibliographies of recent review articles and relevant primary research reports, as… 

Tables from this paper

A systematic review of the use of the ketogenic diet in childhood epilepsy.

Efficacy of ketogenic diets in children with refractory epilepsy: a meta-analysis

The results indicate that a KD is a kind of promising complementary therapy for children with refractory epilepsy, while stricter monitor measures should be implemented for the potential AEs.

Ketogenic diet for treatment of intractable epilepsy in adults: A meta‐analysis of observational studies

The meta‐analysis indicates that the ketogenic diet for refractory epilepsy in adults is a well‐tolerated treatment and that its side effects are acceptable, which show that the KD is a promising treatment in adult intractable epilepsy.

Safety and tolerability of the ketogenic diet used for the treatment of refractory childhood epilepsy: a systematic review of published prospective studies

KD is a relatively safe dietary therapy, but it should be implemented under careful medical supervision, because the KD can cause various AEs, and continuous follow-up is needed to address the long-term impact of the diet on the overall health of children.

Efficiency of the ketogenic diet : treatment of refractory childhood epilepsy

  • Medicine
  • 2015
There should be a recommendation for the ketogenic diet to be offered as a primary option alongside drugs and surgery when trying to treat childhood epilepsy.


Ketogenic diet should be considered as an alternative therapy for children with intractable seizures and is more effective than many of the new anticonvulsant medications and is well tolerated by children and their families.

Ketogenic diet for epilepsy: an overview of systematic review and meta-analysis

The present overview indicates that KDT is safe, and the most prevalent adverse events were GI, weight loss, and metabolic disorders, while the most common reasons for discontinuance were the lack of observed efficacy and dietary intolerance.

Efficacy of The Ketogenic Diet as A Therapy for Intractable Epilepsy in Children

The ketogenic diet should be considered as an alternative therapy for children with intractable seizures and is more effective than many of the new anticonvulsant medications and is well tolerated by children and their families.

Ketogenic Diet For Refractory Epilepsy In Children- An Institutional Experience

The diet was more effective in infantile spasms, Lennox-Gastaut and Dravet syndromes and genetic and structural epilepsies, particularly in malformations of the cortical development.



Efficacy of the Ketogenic Diet for Intractable Seizure Disorders: Review of 58 Cases

Improvement in patients with intractable seizures and the length of time that families maintained the regimen indicate that the ketogenic diet continues to have a very useful therapeutic role in selected patients and their families.

A multicenter study of the efficacy of the ketogenic diet.

The ketogenic diet is effective in substantially decreasing difficult-to-control seizures and can successfully be administered in a wide variety of settings.

Medium‐chain Triglyceride Diet in the Treatment of Intractable Childhood Epilepsy

  • W. Berman
  • Medicine
    Developmental medicine and child neurology
  • 1978
The results with 18 children aged from two to 17 years with intractable childhood epilepsy who were treated with the medium-chain triglycerides (MCT) ketogenic diet at the John F. Kennedy Institute and the Johns Hopkins Hospital, Baltimore, between 1972 and 1974 are reported.


The three ketogenic diets were shown to be effective in the short‐term management of children whose epilepsy is poorly controlled with anticonvulsant drugs.

Alternative Epilepsy Therapies: The Ketogenic Diet, Immunoglobulins, and Steroids

Although the ketogenic diet, immunoglobulins, and steroids may have a role in the treatment of severe childhood epilepsy, all three therapies need to be critically evaluated in regard to efficacy, mechanism of action, and safety.

New antiepileptic drugs: a systematic review of their efficacy and tolerability

Each drug was significantly better than placebo at preventing seizures, but none was significantly different from the others in terms of efficacy or tolerability, though the confidence intervals were wide Randomised trials comparing active treatments are needed to further evaluate these drugs.

Update on epilepsy.

  • E. So
  • Medicine
    The Medical clinics of North America
  • 1993

Medium‐chain triglycerides as a therapy for intractable childhood epilepsy

A diet containing sufficient MCT to induce ketonuria was devised and its effects have been tested in a group of children and adolescents with intractable seizures.

Monotherapy or Polytherapy for Epilepsy Revisited: A Quantitative Assessment

Because distribution of the AED doses was uneven between the groups receiving mono‐ and polytherapy, this study permits only a tentative statement that the frequency and severity of AE is independent of the use of either.

The ketogenic diet: 1997.

The ketogenic diet offers a new paradigm to think about epilepsy and its treatment, and perhaps will stimulate new approaches to this still often devastating condition.