• Corpus ID: 8510265

Ketogenic Diet as a Treatment for Refractory Epilepsy

  title={Ketogenic Diet as a Treatment for Refractory Epilepsy},
  author={Nam Nhut Phan},
  • N. Phan
  • Published 2007
  • Medicine, Psychology
Recent advances in the understanding of the causes of epilepsy have resulted in an increased interest in treatment of this disorder in the past 30 years. With the introduction of more effective anti-epileptic drugs (AED), and genetic, molecular and imaging innovations, epilepsy can be treated effectively in the majority of cases. Although dietary therapy as a means to treat epilepsy has become less popular nowadays with the advent of new AEDs, it is still widely used for children with… 

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Efeito de dieta cetogênica à base de óleo de coco sobre as crises convulsivas de ratos portadores de epilepsia induzida por pilocarpina

A possible protective effect of ketogenic diet based on extra virgin coconut oil on seizures is suggested, coupled with studies attesting to confidence and tolerance of the coconut oil, particularly in ketogenic ratios, indicating a potential benefit of this oil for control the seizures, especially for individuals with medically refractory epilepsy.



Clinical efficacy of the ketogenic diet


The use of diets high in fat and extremely low in carbohydrate in the treatment for idiopathic epilepsy was first suggested by Wilder as a possible substitute for the fasting regimen which had previously been shown by Guelpa and Marie 2 and by Geyelin 3 to influence seizures in many cases.

More fat and fewer seizures: dietary therapies for epilepsy

  • E. Kossoff
  • Medicine, Psychology
    The Lancet Neurology
  • 2004

Epilepsy and Developmental Disability Part I : Developmental Disorders in Which Epilepsy May be Comorbid

While the focus of this paper is on epilepsy in people with a primary developmental disorder, the companion paper, Part II, outlines what is known about the developmental consequences of seizures in neurocognitive and neurobehavioural development.

Characteristics of the epilepsies.

Characteristics of the epilepsy syndromes are discussed, which include the age at seizure onset; seizure type(s); intellectual development; and findings on neurologic examinations, EEGs, and neuroimaging.

Energy metabolism as part of the anticonvulsant mechanism of the ketogenic diet

Several lines of evidence indicate that the ketogenic diet enhances energy production in the brain, and as a consequence, brain tissue appears to become more resistant to metabolic stress.

Ketogenic diet, brain glutamate metabolism and seizure control.