Ketogenic Diet: An Early Option for Epilepsy Treatment, Instead of A Last Choice Only

@article{Wang2013KetogenicDA,
  title={Ketogenic Diet: An Early Option for Epilepsy Treatment, Instead of A Last Choice Only},
  author={Huei-Shyong Wang and Kuang Lin Lin},
  journal={Biomedical Journal},
  year={2013},
  volume={36},
  pages={16 - 17}
}
Ketogenic diet (KD) was usually tried as a last resort in the treatment of intractable epilepsy after failure of many antiepileptics and even epilepsy surgery. Glucose transporter-1 deficiency and pyruvate dehydrogenase deficiency must be treated with KD as the first choice because of inborn errors of glucose metabolism. Infantile spasms, tuberous sclerosis complex, Rett syndrome, Doose syndrome, Dravet syndrome, etc., appear to respond to KD, and it has been suggested by the international… 
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Highly Influential Citations
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28 Citations

Ketogenic Diet Therapy for Epilepsy Management

  • F. Wei
  • Medicine
    Biomedical journal
  • 2013
This special edition includes three review articles on current advances in ketogenic diet therapy for epilepsy management and the classic name, ketogenic Diet therapy, may more appropriately be replaced by the name metabolic diet therapy.

Application of ketogenic diets for pediatric neurocritical care

Neurobiochemical mechanisms of a ketogenic diet in refractory epilepsy

The impacts of the ketogenic diet on the modulation of neurotransmitters, levels of biogenic monoamines and protective antioxidant mechanisms of neurons are highlighted and future perspectives are proposed.

Limited efficacy of the ketogenic diet in the treatment of highly refractory epileptic spasms

Dieta cetogénica no tratamento de epilepsia refratária na Síndrome de Rett

Rett Syndrome is a X-linked rare neurodevelopmental disorder associated MECP2 mutations. The diagnose is clinical and made in the face of a child with an apparently normal psychomotor development…

Efficacy of the ketogenic diet in patients with Dravet syndrome: A meta-analysis

Ketogenic dietary therapies in adults with epilepsy: a practical guide

Here, it is aimed to familiarise adult neurologists with the evidence base for Ketogenic dietary therapies and give practical advice on starting and maintaining them in adults.

Medical and Therapeutic Applications of Ketosis: An Overview

Although the ketogenic diet is controversial, due to its strict dietary protocols, laboratory and clinical research suggest that there are many therapeutic benefits to be reaped through its implementation.

Ketotic hypercalcemia: a case series and description of a novel entity.

  • C. HawkesM. Levine
  • Medicine, Biology
    The Journal of clinical endocrinology and metabolism
  • 2014
Hypercalcemia is an uncommon complication of the ketogenic diet, and these children may represent the severe end of a clinical spectrum of disordered mineral metabolism.

Ketogenic diet in epileptic children: impact on lipoproteins and oxidative stress

Clinicians and researchers are invited to investigate the lipid and oxidative metabolism in their clinical practice and trials, respectively, to update the knowledge about the adverse effects of KD on lipoproteins, lipid profile, and cardiometabolic risk.

References

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    Brain and nerve = Shinkei kenkyu no shinpo
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The history, efficacy, side effects, and possible mechanisms underlying theketogenic diet, as well as the experience with the ketogenic diet at Tokyo Women's Medical University are reviewed.

Dietary Therapies for Epilepsy

Since their introduction in 1921, high-fat, low-carbohydrate "ketogenic" diets have been used worldwide for refractory childhood epilepsy, and for infantile spasms (West syndrome) specifically, the ketogenic diet is successful about 50% of the time as a first-line treatment.

Experience in the Use of the Ketogenic Diet as Early Therapy

In the 13 patients reported, efficacy without side effects was achieved similarly to that with patients with intractable epilepsy, suggesting that the ketogenic diet can be a valuable therapy before epilepsy becomes intractables.

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The Fat is in the Fire: Ketogenic Diet for Refractory Status Epilepticus

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  • Medicine, Psychology
    Epilepsy currents
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The study by Nabbout and her colleagues from five centers in France and Argentina retrospectively examined their use of the ketogenic diet for refractory status epilepticus caused by the condition FIRES, in school age children, the largest study of its kind to report the successful use.

Medium-chain Triglyceride Ketogenic Diet, An Effective Treatment for Drug-resistant Epilepsy and A Comparison with Other Ketogenic Diets

The author has used up to >70% MCTKD diet to maximize seizure control with gastrointestinal side effects optimally controlled, and many more patients with epilepsy who are not appropriate for CKD or modified Atkins diet or low glycemic index treatment will benefit from this treatment.

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The ketogenic diet offers a new paradigm to think about epilepsy and its treatment, and perhaps will stimulate new approaches to this still often devastating condition.

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The ketogenic diet is an efficacious and relatively safe treatment of intractable seizures, and much remains unknown about the diet, including its mechanisms of action, the optimal protocol, and the full range of its applicability.