Ketoconazole inhibits cortisol secretion of an adrenal adenoma in vivo and in vitro

@article{Engelhardt1983KetoconazoleIC,
  title={Ketoconazole inhibits cortisol secretion of an adrenal adenoma in vivo and in vitro},
  author={Prof. Dr. D. Engelhardt and Klaus Mann and Rudolf H{\"o}rmann and Sandra Braun and Hans J{\"o}rg Karl},
  journal={Klinische Wochenschrift},
  year={1983},
  volume={61},
  pages={373-375}
}
Ketoconazole (Nizoral), an oral broad spectrum antifungal agent, inhibits ergosterol synthesis in fungi and cholesterol synthesis in mammalian cells by inhibition of the 14-demethylation of lanosterol. After a blunted cortisol response to ACTH in normal men after ketoconazole has been shown by others we studied the influence of the antifungal agent on the cortisol secretion in a patient with a cortisol producing adrenal adenoma in vivo and in vitro. Repeated oral doses of ketoconazole (200 mg… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-6 of 6 references

Effects of miconazole and ketoconazole on sterol synthesis in a subcellular fraction of yeast and mammalian cells

  • G Willemsens, W Cools, H van den Bossche
  • Van den Bossche H (ed) The host invader interplay…
  • 1980
1 Excerpt

In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthe

  • H Bosschevanden, G Willemsens, W Cools, F Cornelissen, WF Lauwers, JM vanCutsem
  • Antimicrob Agents
  • 1980

In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis

  • H Bossche van den, G Willemsens, W Cools, F Cornelissen, WF Lauwers, JM van Cutsem
  • Antimicrob Agents
  • 1980
1 Excerpt

An improvement of Warburg's method for cutting tissue slices for respiratory experiments

  • W Deutsch
  • J Physiol
  • 1936
1 Excerpt

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