• DOI:10.1093/TOXSCI/40.2.238
Corpus ID: 17194673

Ketoconazole impairs early pregnancy and the decidual cell response via alterations in ovarian function.

@article{Cummings1997KetoconazoleIE,
  title={Ketoconazole impairs early pregnancy and the decidual cell response via alterations in ovarian function.},
  author={A. Cummings and J. Hedge and J. Laskey},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1997},
  volume={40 2},
  pages={
          238-46
        }
}

A. Cummings, J. Hedge, J. Laskey

Published 1997

Medicine, Biology

Fundamental and applied toxicology : official journal of the Society of Toxicology

Ketoconazole (KCZ) is an imidazole antifungal agent that also affects P450 enzymes of the mammalian steroidogenic system. Several steps in the ovarian steroidogenesis pathway are known to be inhibited by KCZ, but previous work has failed to address the ramifications of such inhibition with respect to early pregnancy. In initial studies, Holtzman rats (8-10/group) were administered 10-100 mg/kg KCZ during days 1-8 of pregnancy. On day 9, evaluations revealed a reduction at both 75 and 100 mg KCZ… CONTINUE READING

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