Ketoconazole impairs early pregnancy and the decidual cell response via alterations in ovarian function.

@article{Cummings1997KetoconazoleIE,
  title={Ketoconazole impairs early pregnancy and the decidual cell response via alterations in ovarian function.},
  author={A. Cummings and J. Hedge and J. Laskey},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1997},
  volume={40 2},
  pages={
          238-46
        }
}
  • A. Cummings, J. Hedge, J. Laskey
  • Published 1997
  • Medicine, Biology
  • Fundamental and applied toxicology : official journal of the Society of Toxicology
  • Ketoconazole (KCZ) is an imidazole antifungal agent that also affects P450 enzymes of the mammalian steroidogenic system. Several steps in the ovarian steroidogenesis pathway are known to be inhibited by KCZ, but previous work has failed to address the ramifications of such inhibition with respect to early pregnancy. In initial studies, Holtzman rats (8-10/group) were administered 10-100 mg/kg KCZ during days 1-8 of pregnancy. On day 9, evaluations revealed a reduction at both 75 and 100 mg KCZ… CONTINUE READING
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