Ketoconazole and Miconazole Are Antagonists of the Human Glucocorticoid Receptor: Consequences on the Expression and Function of the Constitutive Androstane Receptor and the Pregnane X Receptor

@article{Duret2006KetoconazoleAM,
  title={Ketoconazole and Miconazole Are Antagonists of the Human Glucocorticoid Receptor: Consequences on the Expression and Function of the Constitutive Androstane Receptor and the Pregnane X Receptor},
  author={C{\'e}dric Duret and Martine Daujat-Chavanieu and Jean-Marc Pascussi and Lydiane Pichard-Garcia and Patrick Balaguer and Jean Michel Fabre and M J Vilarem and Patrick Maurel and Sabine Gerbal-Chaloin},
  journal={Molecular Pharmacology},
  year={2006},
  volume={70},
  pages={329 - 339}
}
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) play a major part in the control of drug metabolism and transport. We have previously shown that PXR and CAR expression is controlled by the glucocorticoid receptor (GR) and proposed the existence of a signal transmission cascade GR-(PXR/CAR)-drug metabolizing and transporter systems. In the current study, we investigated the effect of ketoconazole and other azole-derived drugs, miconazole and fluconazole, on the… Expand
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TLDR
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