Ketoconazole and Miconazole Are Antagonists of the Human Glucocorticoid Receptor: Consequences on the Expression and Function of the Constitutive Androstane Receptor and the Pregnane X Receptor

@article{Duret2006KetoconazoleAM,
  title={Ketoconazole and Miconazole Are Antagonists of the Human Glucocorticoid Receptor: Consequences on the Expression and Function of the Constitutive Androstane Receptor and the Pregnane X Receptor},
  author={C. Duret and Martine Daujat-Chavanieu and J. Pascussi and L. Pichard-Garcia and P. Balaguer and J. Fabre and M. Vilarem and P. Maurel and S. Gerbal-chaloin},
  journal={Molecular Pharmacology},
  year={2006},
  volume={70},
  pages={329 - 339}
}
  • C. Duret, Martine Daujat-Chavanieu, +6 authors S. Gerbal-chaloin
  • Published 2006
  • Biology, Medicine
  • Molecular Pharmacology
  • The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) play a major part in the control of drug metabolism and transport. We have previously shown that PXR and CAR expression is controlled by the glucocorticoid receptor (GR) and proposed the existence of a signal transmission cascade GR-(PXR/CAR)-drug metabolizing and transporter systems. In the current study, we investigated the effect of ketoconazole and other azole-derived drugs, miconazole and fluconazole, on the… CONTINUE READING
    PXR antagonists and implication in drug metabolism
    • 51
    • Highly Influenced
    Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids
    • 80

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