Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis

@inproceedings{Sambandan2013KetoMycolicAP,
  title={Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis},
  author={Dhinakaran Sambandan and Dee N. Dao and Brian Weinrick and Catherine Vilch{\'e}ze and Sudagar S. Gurcha and Anil Kr Ojha and Laurent Kremer and Gurdyal S Besra and Graham F. Hatfull and William Robert Jacobs},
  booktitle={mBio},
  year={2013}
}
ABSTRACT The chronic nature of tuberculosis (TB), its requirement of long duration of treatment, its ability to evade immune intervention, and its propensity to relapse after drug treatment is discontinued are reminiscent of other chronic, biofilm-associated bacterial diseases. Historically, Mycobacterium tuberculosis was grown as a pellicle, a biofilm-like structure, at the liquid-air interface in a variety of synthetic media. Notably, the most widely administered human vaccine, BCG, is grown… CONTINUE READING
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