Ketamine use: a review.

@article{Morgan2012KetamineUA,
  title={Ketamine use: a review.},
  author={C. Morgan and H. Curran},
  journal={Addiction},
  year={2012},
  volume={107 1},
  pages={
          27-38
        }
}
AIMS Ketamine remains an important medicine in both specialist anaesthesia and aspects of pain management. [...] Key MethodMETHOD The literature on ketamine was systematically searched and findings were classified into the matrix of Nutt et al.'s (2007) rational scale for assessing the harms of psychoactive substances. RESULTS A major physical harm is ketamine induced ulcerative cystitis which, although its aetiology is unclear, seems particularly associated with chronic, frequent use of the drug. Frequent…Expand
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Until definite proof is obtained ketamine administration should be restricted to patients with therapy‐resistant severe neuropathic pain, particularly aimed at CNS, haemodynamic, renal and hepatic symptoms as well as abuse. Expand
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The history of ketamine, its growing role as a “dance drug,” the sought-after effects for which it is taken in a nonmedical context, how these are produced, common mental and physical adverse effects, and the ketamine model of schizophrenia are reviewed. Expand
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The authors describe the case of a 52 year old man who has been addicted to ketamine for 15 years and was admitted to hospital to observe and treat the withdrawal syndrome as an effect of abrupt discontinuation of a chronically abused substance. Expand
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A considerable increase in efficacy of the authors' standard alcoholism treatment when supplemented by ketamine psychedelic therapy (KPT) is demonstrated, and these psychological changes were shown to favor a sober lifestyle. Expand
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TLDR
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Reevaluation, though, of analgesic properties of ketamine resulted in new interest regarding its use in perioperative and chronic pain management and recent studies in the effects of the substance on intracranial pressure and cerebral blood flow led to revising the recommendation against itsUse in brain injury. Expand
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Repeated administration of ketamine led to an escalation in the stimulant effects of the drug, characteristic of behavioral sensitization, and this results suggest caution in the repeated use of ketamines for recreational or clinical purposes. Expand
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Findings imply that heavy use of ketamine is harmful to aspects of both cognitive function and psychological wellbeing. Expand
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