Ketamine suppresses the production and release of endothelin 1 from cultured bovine endothelial cells.

@article{Shakunaga1998KetamineST,
  title={Ketamine suppresses the production and release of endothelin 1 from cultured bovine endothelial cells.},
  author={Kiyoshi Shakunaga and Sayuri Kojima and Kayoko Jomura and Yuuki Shimizu and T. Satone and Yusuke Ito},
  journal={Anesthesia and analgesia},
  year={1998},
  volume={86 5},
  pages={1098-102}
}
UNLABELLED Endothelins play important roles in the regulation of vascular tone. We examined the effect of ketamine on the secretion of endothelin 1 (ET-1) and its precursor, "big" ET-1, from bovine carotid artery endothelial cells (BCAECs). After confluent BCAEC cultures were incubated for 24 h with various concentrations of ketamine, the antigen levels for both ET-1 and big ET-1 in the culture medium were determined by using sandwich enzyme-linked immunosorbent assays. The precursor protein ET… CONTINUE READING

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