Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro.

@article{Kawasaki1999KetamineSP,
  title={Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro.},
  author={Takashi Kawasaki and Masanori Ogata and Chika Kawasaki and Junchi Ogata and Yoko Inoue and Akio Shigematsu},
  journal={Anesthesia and analgesia},
  year={1999},
  volume={89 3},
  pages={665-9}
}
UNLABELLED The production of proinflammatory cytokines, such as tumor necrosis factor (TNF) a, interleukin (IL)-6, and IL-8, increases in patients with sepsis; marked production causes organ failure and septic shock. We previously reported that ketamine suppressed lipopolysaccharide (LPS)-induced TNF-alpha production in mice. However, there are no reports on the effect of ketamine on cytokine production in human whole blood. Therefore, in this study, we investigated the efficacy of ketamine on… CONTINUE READING
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