65 Citations
Using the BOLD MR signal to differentiate the stereoisomers of ketamine in the rat
- BiologyNeuroImage
- 2006
Effects of Ketamine and Ketamine Metabolites on Evoked Striatal Dopamine Release, Dopamine Receptors, and Monoamine Transporters
- Biology, PsychologyThe Journal of Pharmacology and Experimental Therapeutics
- 2016
Neither ketamine’s enantiomers nor its metabolites had affinity for DA receptors or the DA, noradrenaline, and serotonin transporters (up to 10 μM), suggesting that neither the side effects nor antidepressant actions of ketamine or ketamine metabolites are associated with direct effects on mesolimbic DAergic neurotransmission.
The ketamine analogue methoxetamine generalizes to ketamine discriminative stimulus in rats
- Biology, PsychologyBehavioural pharmacology
- 2016
The present findings suggest that investigation of ‘ketamine-like compounds’ should explore not only substances with chemical analogy and common molecular mechanisms with ketamine, but also with similar psychopharmacological effects.
(R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism
- Biology, ChemistryThe international journal of neuropsychopharmacology
- 2019
R-Ketamine strongly activates the prefrontal serotonergic system through an AMPA receptor-independent mechanism and provides a neurochemical basis for the underlying pharmacological differences between ketamine enantiomers and their metabolites.
Comparison of ketamine stereoisomers on tissue metabolic activity in an in vitro model of global cerebral ischaemia
- Biology, MedicineNeurochemistry International
- 2001
The monoaminergic pathways and inhibition of monoamine transporters interfere with the antidepressive-like behavior of ketamine
- Biology, PsychologyIBRO reports
- 2018
The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition
- Biology, PsychologyThe Journal of Pharmacology and Experimental Therapeutics
- 2015
4-Cl-KYN administration was not associated with the rewarding and psychotomimetic effects of ketamine, and did not induce locomotor sensitization or stereotypic behaviors, providing further support for antagonism of the glycineB site for the rapid treatment of treatment-resistant depression without the negative side effects seen with ketamine or other channel-blocking NMDA receptor antagonists.
Ketamine’s dose related multiple mechanisms of actions: Dissociative anesthetic to rapid antidepressant
- Biology, PsychologyBehavioural Brain Research
- 2020
Up-regulation of noradrenaline transporter in response to prolonged exposure to ketamine
- Biology, ChemistryNaunyn-Schmiedeberg's Archives of Pharmacology
- 2002
It is demonstrated that prolonged exposure to ketamine increases the functional activity of NAT and its mRNA, which may imply that ketamine negatively modulates sympathetic nervous activity through an up-regulation of NAT during long anaesthesia.
NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D2 and serotonin 5-HT2 receptors—implications for models of schizophrenia
- Biology, PsychologyMolecular Psychiatry
- 2002
Ketamine and PCP may not produce a selective hypoglutamate state, but more likely produce a non-selective multi-system neurochemical perturbation via direct and indirect effects.
References
SHOWING 1-10 OF 20 REFERENCES
Ketamine Inhibits Monoamine Transporters Expressed in Human Embryonic Kidney 293 Cells
- Biology, ChemistryAnesthesiology
- 1998
The result suggests that the ketamine‐induced inhibition of monoamine transporters might contribute to its psychotomimetic and sympathomimetic effects through potentiating monoaminergic neurotransmission.
Synergistic Inhibition of Muscarinic Signaling by Ketamine Stereoisomers and the Preservative Benzethonium Chloride
- Biology, ChemistryAnesthesiology
- 1997
Because S(+) ketamine is a significantly more potent analgesic, it should have less muscarinic inhibitory action than R(‐) ketamine when used in clinically equivalent doses, and if reconstituted with a different preservative, Ketalar might be a less potent mus carinic antagonist.
Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.
- Biology, PsychologyThe Journal of pharmacology and experimental therapeutics
- 1992
In healthy volunteers, the most obvious effect of subanesthetic doses of both enantiomers was altered sensory perception, and (S)-Ketamine was 4 times as potent as (R)-ketamine in reducing pain perception and in causing auditory and visual disturbances.
Comparison of competitive and uncompetitive NMDA receptor antagonists with regard to monoaminergic neuronal activity and behavioural effects in rats.
- Biology, PsychologyEuropean journal of pharmacology
- 1993
Properties of the interaction between ketamine and opiate binding sites in vivo and in vitro
- Biology, ChemistryNeuropharmacology
- 1987
Comparative pharmacology of the ketamine isomers. Studies in volunteers.
- Psychology, BiologyBritish journal of anaesthesia
- 1985
It is concluded that the more potent S(+) isomer of ketamine was associated with a more rapid recovery of psychomotor skills than the currently used racemic mixture.
Cloning and expression of a functional serotonin transporter from rat brain
- BiologyNature
- 1991
A large family of related gene products expressed in rodent brain is identified from two highly conserved regions of the transporters for noradrenaline and γ-aminobutyric acid, and one of these products hybridizes to a single 3.7-kilobase RNA restricted to rat midbrain and brainstem, where it is highly enriched within the serotonergic raphe complex.
Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporter
- BiologyNature
- 1991
A complementary DNA clone encoding a human noradrenaline transporter is isolated and the predicted protein sequence demonstrates significant amino-acid identity with the Na+/γ-aminobutyric acid transporter, thus identifying a new gene family for neurotransmitter transporter proteins.
The inhibitory action of ketamine HCl on [3H]5-hydroxytryptamine accumulation by rat brain synaptosomal-rich fractions: Comparison with [3H]catecholamine and [3H]γ-aminobutyric acid uptake
- Biology, ChemistryNeuropharmacology
- 1977
Ketamine-induced anesthesia involves the N-methyl-d-aspartate
receptor-channel complex in mice
- Biology, MedicineBrain Research
- 1992