Ketamine stereoselectively inhibits rat dopamine transporter

@article{Nishimura1999KetamineSI,
  title={Ketamine stereoselectively inhibits rat dopamine transporter},
  author={M. Nishimura and K. Sato},
  journal={Neuroscience Letters},
  year={1999},
  volume={274},
  pages={131-134}
}
Ketamine is usually administered as a racemate, which is composed of the two isomers, S(+)-and R(-)-ketamine. Recently, we have shown that racemic ketamine at clinical relevant concentrations specifically inhibits the transporter proteins for norepinephrine, dopamine and serotonin heterologously expressed in HEK-293 cells (Nishimura, M., Sato, K., Okada, T., Yoshiya, I., Schloss, P., Shimada, S. and Tohyama, M., Ketamine inhibits monoamine transporters expressed in human embryonic kidney 293… Expand
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References

SHOWING 1-10 OF 20 REFERENCES
Ketamine Inhibits Monoamine Transporters Expressed in Human Embryonic Kidney 293 Cells
  • 99
Synergistic Inhibition of Muscarinic Signaling by Ketamine Stereoisomers and the Preservative Benzethonium Chloride
  • 35
Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.
  • 374
Comparison of competitive and uncompetitive NMDA receptor antagonists with regard to monoaminergic neuronal activity and behavioural effects in rats.
  • 78
Properties of the interaction between ketamine and opiate binding sites in vivo and in vitro
  • 188
Comparative pharmacology of the ketamine isomers. Studies in volunteers.
  • 314
Cloning and expression of a functional serotonin transporter from rat brain
  • 756
Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporter
  • 874
The inhibitory action of ketamine HCl on [3H]5-hydroxytryptamine accumulation by rat brain synaptosomal-rich fractions: Comparison with [3H]catecholamine and [3H]γ-aminobutyric acid uptake
  • 47
Ketamine-induced anesthesia involves the N-methyl-d-aspartate receptor-channel complex in mice
  • 134
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