Ketamine stereoselectively inhibits rat dopamine transporter

@article{Nishimura1999KetamineSI,
  title={Ketamine stereoselectively inhibits rat dopamine transporter},
  author={Mitsuhiro Nishimura and K. Sato},
  journal={Neuroscience Letters},
  year={1999},
  volume={274},
  pages={131-134}
}
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References

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The result suggests that the ketamine‐induced inhibition of monoamine transporters might contribute to its psychotomimetic and sympathomimetic effects through potentiating monoaminergic neurotransmission.
Synergistic Inhibition of Muscarinic Signaling by Ketamine Stereoisomers and the Preservative Benzethonium Chloride
TLDR
Because S(+) ketamine is a significantly more potent analgesic, it should have less muscarinic inhibitory action than R(‐) ketamine when used in clinically equivalent doses, and if reconstituted with a different preservative, Ketalar might be a less potent mus carinic antagonist.
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In healthy volunteers, the most obvious effect of subanesthetic doses of both enantiomers was altered sensory perception, and (S)-Ketamine was 4 times as potent as (R)-ketamine in reducing pain perception and in causing auditory and visual disturbances.
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TLDR
It is concluded that the more potent S(+) isomer of ketamine was associated with a more rapid recovery of psychomotor skills than the currently used racemic mixture.
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TLDR
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TLDR
A complementary DNA clone encoding a human noradrenaline transporter is isolated and the predicted protein sequence demonstrates significant amino-acid identity with the Na+/γ-aminobutyric acid transporter, thus identifying a new gene family for neurotransmitter transporter proteins.
The inhibitory action of ketamine HCl on [3H]5-hydroxytryptamine accumulation by rat brain synaptosomal-rich fractions: Comparison with [3H]catecholamine and [3H]γ-aminobutyric acid uptake
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