Ketamine reverses stress-induced depression-like behavior and increased GABA levels in the anterior cingulate: An 11.7<ce:hsp sp=0.25></ce:hsp>T <ce:sup loc=pre>1</ce:sup>H-MRS study in rats

@article{Perrine2014KetamineRS,
  title={Ketamine reverses stress-induced depression-like behavior and increased GABA levels in the anterior cingulate: An 11.7<ce:hsp sp=0.25></ce:hsp>T <ce:sup loc=pre>1</ce:sup>H-MRS study in rats},
  author={Shane Alan Perrine and Farhad Ghoddoussi and Mark S. Michaels and Imran Sohail Sheikh and Matthew Peter Galloway},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2014},
  volume={51},
  pages={9-15}
}
Gamma-aminobutyric acid (GABA) is the major inhibitory amino acid neurotransmitter in the brain and is primarily responsible for modulating excitatory tone. Clinical neuroimaging studies show decreased GABA levels in the anterior cingulate of patients with mood disorders, including major depressive disorder. Chronic unpredictable stress (CUS) is an animal model thought to mimic the stressful events that may precipitate clinical depression in humans. In this study male Sprague-Dawley rats were… CONTINUE READING

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