Ketamine modulates subgenual cingulate connectivity with the memory-related neural circuit—a mechanism of relevance to resistant depression?

@inproceedings{Wong2016KetamineMS,
  title={Ketamine modulates subgenual cingulate connectivity with the memory-related neural circuit—a mechanism of relevance to resistant depression?},
  author={J. J. Wong and Owen G. O’Daly and Mitul A. Mehta and Allan Hunter Young and James M Stone and Bob D. Patton},
  booktitle={PeerJ},
  year={2016}
}
Background. Ketamine has been reported to have efficacy as an antidepressant in several studies of treatment-resistant depression. In this study, we investigate whether an acute administration of ketamine leads to reductions in the functional connectivity of subgenual anterior cingulate cortex (sgACC) with other brain regions. Methods. Thirteen right-handed healthy male subjects underwent a 15 min resting state fMRI with an infusion of intravenous ketamine (target blood level = 150 ng/ml… CONTINUE READING
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Perceptual distortions and delusional thinking following ketamine administration are related Wong et al

  • J Stone, V Kotoula, C Dietrich, S De Simoni, JH Krystal, MA. Mehta
  • (2016), PeerJ, DOI 10.7717/peerj.1710
  • 2015
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