Ketamine inhibits endotoxin-induced shock in rats.

  title={Ketamine inhibits endotoxin-induced shock in rats.},
  author={Takumi Taniguchi and Keizo Shibata and Kazuo Yamamoto},
  volume={95 4},
BACKGROUND Cytokines and nitric oxide are believed to participate importantly in the pathogenesis of endotoxin-induced shock. Several investigators have documented that ketamine attenuates production of cytokines and nitric oxide in endotoxemia, but little is known concerning hemodynamic effects of the drug in this state. The objective of the current study was to assess the potential modifying effects of ketamine in endotoxemia. METHODS The authors randomly assigned 40 rats to one of four… CONTINUE READING