Ketamine induces a robust whole-brain connectivity pattern that can be differentially modulated by drugs of different mechanism and clinical profile

@inproceedings{Joules2015KetamineIA,
  title={Ketamine induces a robust whole-brain connectivity pattern that can be differentially modulated by drugs of different mechanism and clinical profile},
  author={R. Joules and Orla M. Doyle and Adam J Schwarz and Owen G. O’Daly and Michael J. Brammer and Steven C. R. Williams and Mitul A. Mehta},
  booktitle={Psychopharmacology},
  year={2015}
}
Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, has been studied in relation to the glutamate hypothesis of schizophrenia and increases dissociation, positive and negative symptom ratings. Ketamine effects brain function through changes in brain activity; these activity patterns can be modulated by pre-treatment of compounds known to attenuate the effects of ketamine on glutamate release. Ketamine also has marked effects on brain connectivity; we predicted that these changes… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
18 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Test-retest reliability of the BOLD pharmacological MRI response to ketamine in healthy volunteers

  • S De Simoni, AJ Schwarz
  • Neuroimage
  • 2013

Similar Papers

Loading similar papers…