Ketamine-induced potentiation of morphine analgesia in rat tail-flick test: role of opioid-, alpha2-adrenoceptors and ATP-sensitive potassium channels.

@article{Campos2006KetamineinducedPO,
  title={Ketamine-induced potentiation of morphine analgesia in rat tail-flick test: role of opioid-, alpha2-adrenoceptors and ATP-sensitive potassium channels.},
  author={Adriana Rolim Campos and Fl{\'a}via Santos and Vietla Satyanarayana Rao},
  journal={Biological & pharmaceutical bulletin},
  year={2006},
  volume={29 1},
  pages={86-9}
}
Ketamine is known to improve opioid efficacy, reduce postoperative opioid requirement and oppose opioid associated pain hypersensitivity and tolerance. However, the mechanisms underlying these beneficial effects are not clear. This study investigated the effects of ketamine at a non-analgesic dose (30 mg/kg, i.p.) on analgesia induced by morphine (2.5, 5.0, 7.5 mg/kg, s.c.), using rat tail-flick test as an animal model of acute pain. Further, the role of opioid-, alpha2-adrenoceptors and ATP… CONTINUE READING
7 Citations
2 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Humana Press, Totowa

  • M. Kavaliers
  • 1996

Motor Activity

  • P R.Sanberg, M. Rodrigo, R D.Shytle, D W.Cahill
  • 1941

Similar Papers

Loading similar papers…