Ketamine-induced hyperlocomotion associated with alteration of presynaptic components of dopamine neurons in the nucleus accumbens of mice.

@article{Irifune1991KetamineinducedHA,
  title={Ketamine-induced hyperlocomotion associated with alteration of presynaptic components of dopamine neurons in the nucleus accumbens of mice.},
  author={Masahiro Irifune and Takahiro Shimizu and Masahiro Nomoto},
  journal={Pharmacology, biochemistry, and behavior},
  year={1991},
  volume={40 2},
  pages={399-407}
}
The underlying mechanisms of ketamine-induced hyperlocomotion were examined in mice. An intraperitoneal (IP) injection of ketamine (3-150 mg/kg) increased locomotor activity in a dose-dependent fashion. A low dose of ketamine (30 mg/kg) produced peak locomotion within the first 10 min followed by a rapid decline. In contrast, a high dose (150 mg/kg) inhibited locomotor activity to the control level during the first 30 min. Thereafter the activity gradually increased and reached a peak at… CONTINUE READING

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