Ketamine increases human motor cortex excitability to transcranial magnetic stimulation.

@article{Lazzaro2003KetamineIH,
  title={Ketamine increases human motor cortex excitability to transcranial magnetic stimulation.},
  author={Vincenzo Di Lazzaro and Antonio Oliviero and Paolo Profice and Mariano Alberto Pennisi and Fabio Pilato and Giancarlo Zito and Michele Dileone and Roberto Nicoletti and Patrizio Pasqualetti and Pietro A. Tonali},
  journal={The Journal of physiology},
  year={2003},
  volume={547 Pt 2},
  pages={485-96}
}
Subanaesthetic doses of the N-methyl-D-aspartate (NMDA) antagonist ketamine have been shown to determine a dual modulating effect on glutamatergic transmission in experimental animals, blocking NMDA receptor activity and enhancing non-NMDA transmission through an increase in the release of endogenous glutamate. Little is known about the effects of ketamine on the excitability of the human central nervous system. The effects of subanaesthetic, graded incremental doses of ketamine (0.01, 0.02 and… CONTINUE READING

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