Ketamine enhances human neural stem cell proliferation and induces neuronal apoptosis via reactive oxygen species-mediated mitochondrial pathway.

@article{Bai2013KetamineEH,
  title={Ketamine enhances human neural stem cell proliferation and induces neuronal apoptosis via reactive oxygen species-mediated mitochondrial pathway.},
  author={Xiaowen Bai and Yasheng Yan and Scott G Canfield and Maria Yu. Muravyeva and Chika Kikuchi and Ivan Zaja and John A Corbett and Zeljko J Bosnjak},
  journal={Anesthesia and analgesia},
  year={2013},
  volume={116 4},
  pages={869-80}
}
BACKGROUND Growing evidence indicates that ketamine causes neurotoxicity in a variety of developing animal models, leading to a serious concern regarding the safety of pediatric anesthesia. However, if and how ketamine induces human neural cell toxicity is unknown. Recapitulation of neurogenesis from human embryonic stem cells (hESCs) in vitro allows investigation of the toxic effects of ketamine on neural stem cells (NSCs) and developing neurons, which is impossible to perform in humans. In… CONTINUE READING
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