Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism

Abstract

Behavioural antidepressant-like effects of ketamine have been reported in the forced swimming test (FST). The mechanisms mediating such effects are unknown. As serotonin (5-HT) is an important transmitter mediating antidepressant responsiveness in the FST, the influence of 5-HT depletion on the antidepressant-like effect of ketamine was assessed. The effect… (More)
DOI: 10.1007/s00213-013-3024-x

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