Ketamine dose-dependently induces high-frequency oscillations in the nucleus accumbens in freely moving rats.

@article{Hunt2006KetamineDI,
  title={Ketamine dose-dependently induces high-frequency oscillations in the nucleus accumbens in freely moving rats.},
  author={M. J. Hunt and Beryl Raynaud and Rene Henriquez Garcia},
  journal={Biological psychiatry},
  year={2006},
  volume={60 11},
  pages={1206-14}
}
BACKGROUND In humans, subanesthetic doses of ketamine and recovery from ketamine anesthesia are associated with psychotic-like behavior. In rodents, ketamine produces hyperactivity, stereotypies, and abnormal social interaction used to model certain features of schizophrenia. Increasing evidence has implicated aberrant activity in the nucleus accumbens (NAc) with the pathophysiology of schizophrenia. METHODS Here, we examined the effect of an IP injection of ketamine (10, 25, 50, and 200 mg… CONTINUE READING
42 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Similar Papers

Loading similar papers…