Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn

@article{Meyer2013KetaminederivedDD,
  title={Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn},
  author={Markus R. Meyer and Michelle Bach and J{\'e}ssica Welter and Michael Bovens and Alain Turcant and Hans H. Maurer},
  journal={Analytical and Bioanalytical Chemistry},
  year={2013},
  volume={405},
  pages={6307-6321}
}
Methoxetamine (MXE; 2-(3-methoxyphenyl)-2-(N-ethylamino)-cyclohexanone), a ketamine analog, is a new designer drug and synthesized for its longer lasting and favorable pharmacological effects over ketamine. The aims of the presented study were to identify the phases I and II metabolites of MXE in rat and human urine by GC-MS and LC-high-resolution (HR)-MSn and to evaluate their detectability by GC-MS and LC-MSn using authors’ standard urine screening approaches (SUSAs). Furthermore, human… 

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