Ketamine depresses toll-like receptor 3 signaling in spinal microglia in a rat model of neuropathic pain.

@article{Mei2011KetamineDT,
  title={Ketamine depresses toll-like receptor 3 signaling in spinal microglia in a rat model of neuropathic pain.},
  author={Xiao-Peng Mei and Yang Zhou and Wei Wang and Jun Tang and Wen Wang and Hui Zhang and Li-xian Xu and Yun-qing Li},
  journal={Neuro-Signals},
  year={2011},
  volume={19 1},
  pages={44-53}
}
Reports suggest that microglia play a key role in spinal nerve ligation (SNL)-induced neuropathic pain, and toll-like receptor 3 (TLR3) has a substantial role in the activation of spinal microglia and the development of tactile allodynia after nerve injury. In addition, ketamine application could suppress microglial activation in vitro, and ketamine could inhibit proinflammatory gene expression possibly by suppressing TLR-mediated signal transduction. Therefore, the present study was designed… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Similar Papers

Loading similar papers…