Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

  title={Ketamine blocks bursting in the lateral habenula to rapidly relieve depression},
  author={Y. Yang and Yihui Cui and K. Sang and Yiyan Dong and Zheyi Ni and S. Ma and H. Hu},
  • Y. Yang, Yihui Cui, +4 authors H. Hu
  • Published 2018
  • Medicine
  • Nature
  • The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine has attracted enormous interest in mental health research owing to its rapid antidepressant actions, but its mechanism of action has remained elusive. [...] Key Result LHb neurons show a significant increase in burst activity and theta-band synchronization in depressive-like animals, which is reversed by ketamine. Burst-evoking photostimulation of LHb drives behavioural despair and anhedonia.Expand Abstract
    263 Citations

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