Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

@article{Yang2018KetamineBB,
  title={Ketamine blocks bursting in the lateral habenula to rapidly relieve depression},
  author={Y. Yang and Yihui Cui and K. Sang and Yiyan Dong and Zheyi Ni and S. Ma and H. Hu},
  journal={Nature},
  year={2018},
  volume={554},
  pages={317-322}
}
  • Y. Yang, Yihui Cui, +4 authors H. Hu
  • Published 2018
  • Medicine
  • Nature
  • The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine has attracted enormous interest in mental health research owing to its rapid antidepressant actions, but its mechanism of action has remained elusive. [...] Key Result LHb neurons show a significant increase in burst activity and theta-band synchronization in depressive-like animals, which is reversed by ketamine. Burst-evoking photostimulation of LHb drives behavioural despair and anhedonia.Expand Abstract
    263 Citations

    Paper Mentions

    Interventional Clinical Trial
    This study evaluates the efficacy and safety of ethosuximide in the treatment of refractory depressive disorder in adults. Half of participants will receive ethosuximide and… Expand
    ConditionsDepressive Disorder, Treatment-Resistant
    InterventionDrug
    Interventional Clinical Trial
    Mexico, prevalence reported for major depressive disorder (MDD) is of 7.2%. It is currently in the top 5 causes of disability worldwide. One third of patients will not achieve remission… Expand
    ConditionsTreatment Resistant Depression
    InterventionDrug
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