Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

@article{Yang2018KetamineBB,
  title={Ketamine blocks bursting in the lateral habenula to rapidly relieve depression},
  author={Yan Yang and Yihui Cui and Kangning Sang and Yiyan Dong and Zheyi Ni and Shuangshuang Ma and Hailan Hu},
  journal={Nature},
  year={2018},
  volume={554},
  pages={317-322}
}
The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine has attracted enormous interest in mental health research owing to its rapid antidepressant actions, but its mechanism of action has remained elusive. [] Key Result LHb neurons show a significant increase in burst activity and theta-band synchronization in depressive-like animals, which is reversed by ketamine. Burst-evoking photostimulation of LHb drives behavioural despair and anhedonia.
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457 Citations

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