• DOI:10.1038/nature25509
Corpus ID: 3334820

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

@article{Yang2018KetamineBB,
  title={Ketamine blocks bursting in the lateral habenula to rapidly relieve depression},
  author={Y. Yang and Yihui Cui and K. Sang and Yiyan Dong and Zheyi Ni and S. Ma and H. Hu},
  journal={Nature},
  year={2018},
  volume={554},
  pages={317-322}
}

• Y. Yang, Yihui Cui, +4 authors H. Hu
• Published 2018
• Medicine
• Nature

The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine has attracted enormous interest in mental health research owing to its rapid antidepressant actions, but its mechanism of action has remained elusive. [...] Key Result LHb neurons show a significant increase in burst activity and theta-band synchronization in depressive-like animals, which is reversed by ketamine. Burst-evoking photostimulation of LHb drives behavioural despair and anhedonia.Expand

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