Ketamine blocks bursting in the lateral habenula to rapidly relieve depression
@article{Yang2018KetamineBB, title={Ketamine blocks bursting in the lateral habenula to rapidly relieve depression}, author={Y. Yang and Yihui Cui and K. Sang and Yiyan Dong and Zheyi Ni and S. Ma and H. Hu}, journal={Nature}, year={2018}, volume={554}, pages={317-322} }
The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine has attracted enormous interest in mental health research owing to its rapid antidepressant actions, but its mechanism of action has remained elusive. [...] Key Result LHb neurons show a significant increase in burst activity and theta-band synchronization in depressive-like animals, which is reversed by ketamine. Burst-evoking photostimulation of LHb drives behavioural despair and anhedonia.Expand
Paper Mentions
Interventional Clinical Trial
This study evaluates the efficacy and safety of ethosuximide in the treatment of refractory
depressive disorder in adults. Half of participants will receive ethosuximide and… Expand
Conditions | Depressive Disorder, Treatment-Resistant |
---|---|
Intervention | Drug |
Interventional Clinical Trial
Mexico, prevalence reported for major depressive disorder (MDD) is of 7.2%. It is currently
in the top 5 causes of disability worldwide. One third of patients will not achieve remission… Expand
Conditions | Treatment Resistant Depression |
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Intervention | Drug |
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References
SHOWING 1-10 OF 58 REFERENCES
NMDA Receptor Blockade at Rest Triggers Rapid Behavioural Antidepressant Responses
- Medicine
- Nature
- 2011
- 1,222
- PDF
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
- Biology, Medicine
- Science
- 2010
- 1,820
- PDF
Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism
- Psychology, Medicine
- Psychopharmacology
- 2013
- 104
Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses
- Psychology, Medicine
- Proceedings of the National Academy of Sciences
- 2014
- 146
- PDF
Synaptic potentiation onto habenula neurons in learned helplessness model of depression
- Biology, Medicine
- Nature
- 2011
- 399
- PDF
GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment
- Chemistry, Medicine
- Science
- 2014
- 201
Fluoxetine impairs GABAergic signaling in hippocampal slices from neonatal rats
- Biology, Medicine
- Front. Cell. Neurosci.
- 2013
- 13
Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors
- Chemistry, Medicine
- Biological Psychiatry
- 2008
- 888