Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

@article{Yang2018KetamineBB,
  title={Ketamine blocks bursting in the lateral habenula to rapidly relieve depression},
  author={Y. Yang and Yihui Cui and K. Sang and Yiyan Dong and Zheyi Ni and S. Ma and H. Hu},
  journal={Nature},
  year={2018},
  volume={554},
  pages={317-322}
}
The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine has attracted enormous interest in mental health research owing to its rapid antidepressant actions, but its mechanism of action has remained elusive. [...] Key Result LHb neurons show a significant increase in burst activity and theta-band synchronization in depressive-like animals, which is reversed by ketamine. Burst-evoking photostimulation of LHb drives behavioural despair and anhedonia.Expand
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Paper Mentions

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This study evaluates the efficacy and safety of ethosuximide in the treatment of refractory depressive disorder in adults. Half of participants will receive ethosuximide and… Expand
ConditionsDepressive Disorder, Treatment-Resistant
InterventionDrug
Interventional Clinical Trial
Mexico, prevalence reported for major depressive disorder (MDD) is of 7.2%. It is currently in the top 5 causes of disability worldwide. One third of patients will not achieve remission… Expand
ConditionsTreatment Resistant Depression
InterventionDrug
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