Ketamine as the prototype glutamatergic antidepressant: pharmacodynamic actions, and a systematic review and meta-analysis of efficacy.

@article{Caddy2014KetamineAT,
  title={Ketamine as the prototype glutamatergic antidepressant: pharmacodynamic actions, and a systematic review and meta-analysis of efficacy.},
  author={Caroline Caddy and Giovanni Giaroli and Thomas P. White and Sukhwinder S. Shergill and Derek Kenneth Tracy},
  journal={Therapeutic advances in psychopharmacology},
  year={2014},
  volume={4 2},
  pages={75-99}
}
The burden of depressive disorders and the frequent inadequacy of their current pharmacological treatments are well established. The anaesthetic and hallucinogenic drug ketamine has provoked much interest over the past decade or so as an extremely rapidly acting antidepressant that does not modify 'classical' monoaminergic receptors. Current evidence has shown several ways through which it might exert therapeutic antidepressant actions: blockade of glutamatergic NMDA receptors and relative… CONTINUE READING
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