Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review.

@article{Iadarola2015KetamineAO,
  title={Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review.},
  author={Nicolas D. Iadarola and Mark J. Niciu and Erica M. Richards and Jennifer L Vande Voort and Elizabeth D Ballard and Nancy B Lundin and Allison C. Nugent and Rodrigo Machado-Vieira and Carlos A. Zarate},
  journal={Therapeutic advances in chronic disease},
  year={2015},
  volume={6 3},
  pages={97-114}
}
Current pharmacotherapies for major depressive disorder (MDD) and bipolar depression (BDep) have a distinct lag of onset that can generate great distress and impairment in patients. Furthermore, as demonstrated by several real-world effectiveness trials, their efficacy is limited. All approved antidepressant medications for MDD primarily act through… CONTINUE READING