Ketamine and norketamine plasma concentrations after i.v., nasal and rectal administration in children.

@article{Malinovsky1996KetamineAN,
  title={Ketamine and norketamine plasma concentrations after i.v., nasal and rectal administration in children.},
  author={J M Malinovsky and Fr{\'e}d{\'e}rique Servin and Antoine Cozian and J Y Lepage and Michel Pinaud},
  journal={British journal of anaesthesia},
  year={1996},
  volume={77 2},
  pages={203-7}
}
It has been suggested that nasal administration of ketamine may be used to induce anaesthesia in paediatric patients. We have examined the pharmacokinetics of ketamine and norketamine after nasal administration compared with rectal and i.v. administration in young children. During halothane anaesthesia, 32 children, aged 2-9 yr, weight 10-30 kg, were allocated randomly to receive ketamine 3 mg kg-1 nasally (group IN3) or ketamine 9 mg kg-1 nasally (group IN9); ketamine 9 mg kg-1 rectally (group… CONTINUE READING
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