Ketamine alters oscillatory coupling in the hippocampus

  title={Ketamine alters oscillatory coupling in the hippocampus},
  author={F{\'a}bio Viegas Caixeta and Alianda Maira Corn{\'e}lio and Robson Scheffer-Teixeira and Sidarta Ribeiro and Adriano B. L. Tort},
  booktitle={Scientific reports},
Recent studies show that higher order oscillatory interactions such as cross-frequency coupling are important for brain functions that are impaired in schizophrenia, including perception, attention and memory. Here we investigated the dynamics of oscillatory coupling in the hippocampus of awake rats upon NMDA receptor blockade by ketamine, a pharmacological model of schizophrenia. Ketamine (25, 50 and 75 mg/kg i.p.) increased gamma and high-frequency oscillations (HFO) in all depths of the CA1… CONTINUE READING
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