Ketamine Influences CLOCK:BMAL1 Function Leading to Altered Circadian Gene Expression

@inproceedings{Bellet2011KetamineIC,
  title={Ketamine Influences CLOCK:BMAL1 Function Leading to Altered Circadian Gene Expression},
  author={Marina M Bellet and Marquis P. Vawter and Blynn G Bunney and William E. Bunney and Paolo Sassone-Corsi},
  booktitle={PloS one},
  year={2011}
}
Major mood disorders have been linked to abnormalities in circadian rhythms, leading to disturbances in sleep, mood, temperature, and hormonal levels. We provide evidence that ketamine, a drug with rapid antidepressant effects, influences the function of the circadian molecular machinery. Ketamine modulates CLOCK:BMAL1-mediated transcriptional activation when these regulators are ectopically expressed in NG108-15 neuronal cells. Inhibition occurs in a dose-dependent manner and is attenuated… CONTINUE READING
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