Ketamine Increases Permeability and Alters Epithelial Phenotype of Renal Distal Tubular Cells via a GSK-3β-Dependent Mechanism.

@article{Shyu2016KetamineIP,
  title={Ketamine Increases Permeability and Alters Epithelial Phenotype of Renal Distal Tubular Cells via a GSK-3β-Dependent Mechanism.},
  author={Hsin-Yi Shyu and Chun-Jung Ko and Yu-Chen Luo and Hsin-Ying Lin and Shang-Ru Wu and Shao-Wei Lan and Tai-shan Cheng and Shih-Hsiung Hu and Ming-Shyue Lee},
  journal={Journal of cellular biochemistry},
  year={2016},
  volume={117 4},
  pages={
          881-93
        }
}
Ketamine, a dissociative anesthetic, is misused and abused worldwide as an illegal recreational drug. In addition to its neuropathic toxicity, ketamine abuse has numerous effects, including renal failure; however, the underlying mechanism is poorly understood. The process called epithelial phenotypic changes (EPCs) causes the loss of cell-cell adhesion and cell polarity in renal diseases, as well as the acquisition of migratory and invasive properties. Madin-Darby canine kidney cells, an in… CONTINUE READING
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