Ketamine’s antidepressant action: beyond NMDA receptor inhibition

@article{Hashimoto2016KetaminesAA,
  title={Ketamine’s antidepressant action: beyond NMDA receptor inhibition},
  author={K. Hashimoto},
  journal={Expert Opinion on Therapeutic Targets},
  year={2016},
  volume={20},
  pages={1389 - 1392}
}
  • K. Hashimoto
  • Published 2016
  • Medicine
  • Expert Opinion on Therapeutic Targets
ABSTRACT The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine is one of the most attractive antidepressants since this drug causes rapid-onset and sustained antidepressant effects in treatment resistant patients with depression. There are unanswered questions about how ketamine induces its rapid and sustained antidepressant actions. This key article suggests that (2R,6R)-HNK (hydroxynorketamine), a major metabolite of (R)-ketamine, shows antidepressant effects in rodent models of… Expand
View on Taylor & Francis
embodimentcounselling.com
45 Citations
Background Citations
14
Results Citations
1

45 Citations

Citation Type

Citation Type

Antidepressant Actions of Ketamine and Its Two Enantiomers
Rapid Antidepressant Activity of Ketamine Beyond NMDA Receptor
  • 14
Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites
  • 36
  • PDF
AMPA Receptor Activation–Independent Antidepressant Actions of Ketamine Metabolite (S)-Norketamine
  • 37
Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine’s Antidepressant Action
  • 9
Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine.
  • 5
An update on ketamine and its two enantiomers as rapid-acting antidepressants
  • 40
Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine
  • 110
  • PDF
5-Hydroxytryptamine-Independent Antidepressant Actions of (R)-Ketamine in a Chronic Social Defeat Stress Model
  • 23
  • PDF
A historical review of antidepressant effects of ketamine and its enantiomers
  • 22
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 15 REFERENCES
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
  • 752
  • PDF
Antidepressant effects of ketamine in depressed patients
  • 2,344
  • PDF
R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects
  • 268
R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine
  • 168
Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression
  • 113
Loss of parvalbumin-immunoreactivity in mouse brain regions after repeated intermittent administration of esketamine, but not R-ketamine
  • 58
Reduction of dopamine D2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys
  • 66
  • PDF
Single-dose infusion ketamine and non-ketamine N-methyl-d-aspartate receptor antagonists for unipolar and bipolar depression: a meta-analysis of efficacy, safety and time trajectories.
  • 160
  • PDF
Effects of a single bilateral infusion of R-ketamine in the rat brain regions of a learned helplessness model of depression
  • 42
Detrimental Side Effects of Repeated Ketamine Infusions in the Brain.
  • K. Hashimoto
  • Psychology, Medicine
  • The American journal of psychiatry
  • 2016
  • 27
...
1
2
...