Ketamine’s antidepressant action: beyond NMDA receptor inhibition

@article{Hashimoto2016KetaminesAA,
  title={Ketamine’s antidepressant action: beyond NMDA receptor inhibition},
  author={K. Hashimoto},
  journal={Expert Opinion on Therapeutic Targets},
  year={2016},
  volume={20},
  pages={1389 - 1392}
}
  • K. Hashimoto
  • Published 2016
  • Medicine
  • Expert Opinion on Therapeutic Targets
ABSTRACT The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine is one of the most attractive antidepressants since this drug causes rapid-onset and sustained antidepressant effects in treatment resistant patients with depression. There are unanswered questions about how ketamine induces its rapid and sustained antidepressant actions. This key article suggests that (2R,6R)-HNK (hydroxynorketamine), a major metabolite of (R)-ketamine, shows antidepressant effects in rodent models of… Expand
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