Ketamine‐induced vesicopathy: a literature review

  title={Ketamine‐induced vesicopathy: a literature review},
  author={Seshikanth Middela and Ian A. Pearce},
  journal={International Journal of Clinical Practice},
  • S. Middela, I. Pearce
  • Published 1 January 2011
  • Medicine
  • International Journal of Clinical Practice
Ketamine consumption in on the increase as a recreational abuse substance. It is reported to cause lower urinary tract symptoms (LUTS), and published accounts of its deleterious effects are increasing. We reviewed the available literature regarding the urological impact of ketamine abuse and its management. Twenty‐two publications were found in total after a search of all databases including Pubmed, Medline and Google Scholar using the words ‘ketamine’, ‘bladder’ and ‘cystitis’ with no limits… 
A Review Of The Literature On Ketamine-Abuse-Uropathy
A review of a number of cases of Ketamine abuse uropathy which have been reported in the literature and a great need for the public to be educated about the devastating effect of ketamine abuse on the urinary tract in order to dissuade people from abusing ketamine.
Ketamine cystitis: Its urological impact and management
Interstitial cystitis symptoms associated with ketamine abuse: The first Japanese case
This is the first Japanese case report of IC symptoms associated with ketamine abuse, and the patient’s medical course suggests that discontinuation of ketamine and hydrodistension of the bladder may result in spontaneous improvement of the symptoms, even after long-term exposure to the agent.
Ketamine-Associated Urinary Tract Dysfunction: An Underrecognized Clinical Entity
Ketamine-associated urinary tract dysfunction appears to be a relatively new clinical phenomenon and current management strategies are ketamine cessation along with intravesical sodium hyaluronate solution.
Delayed Urinary Symptoms Induced by Ketamine
Future research should follow up patients who at some point in their life made an abusive consumption of ketamine in order to understand the pathogenesis and to be able to intervene before clinical disease manifests itself.
Ketamine is associated with lower urinary tract signs and symptoms.
Vascular fibrinoid necrosis in the urinary bladder of ketamine abusers: A new finding that may provide a clue to the pathogenesis of ketamine‐induced vesicopathy
Two 31‐year‐old women who had abused ketamine presented with ketamine‐induced vesicopathy with urinary frequency, decreased bladder capacity, and detrusor overactivity, and the pathology of the urinary bladders showed ulcerative cystitis and fibrinoid necrosis of vessels; the latter was confirmed by Masson trichrome staining.


Cystitis due to the use of ketamine as a recreational drug: a case report
It is expected that in the future an increasing number of cases of cystitis caused by ketamine use will be seen in young adults.
Cystitis associated with chronic ketamine abuse
Both of the present cases demonstrated strong temporal association between ketamine use and cystitis, and one case report indicated a dose-related effect of ketamine on the bladder, a finding that may explain the limited symptom resolution in the second case, in which a higher dose of ketamines was involved.
Street ketamine-associated bladder dysfunction: an emerging health problem.
A new clinical entity of severe bladder dysfunction associated with chronic abuse of street ketamine, which is refractory to conventional treatment and awareness of this new condition is essential in diagnosis.
Can ketamine prescribed for pain cause damage to the urinary tract?
Presentation of three palliative care patients who were given ketamine as an analgesic and subsequently developed significant and debilitating urological symptoms and possible mechanisms for damage to the urothelium by ketamine are suggested.
Supravesical diversion for incontinence: a long-term follow-up.
Supravesical diversion is safe and well tolerated but assessing the long-term follow-up, the incidence of bladder problems in over half these patients and upper tract changes in over a third suggests an indefinite follow- up is mandatory.
Ketamine associated cystitis - a case report.
  • R. Hoskins
  • Medicine
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  • 2009